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Thalidomide-NH-PEG1-NH2 hydrochloride

CAS No. 2154342-56-8

Thalidomide-NH-PEG1-NH2 hydrochloride( 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl )

Catalog No. M28662 CAS No. 2154342-56-8

Thalidomide-NH-PEG1-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Thalidomide-NH-PEG1-NH2 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Thalidomide-NH-PEG1-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker.
  • Description
    Thalidomide-NH-PEG1-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TGFβRI
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2154342-56-8
  • Formula Weight
    396.83
  • Molecular Formula
    C17H21ClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCN)=O.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Flavia Mercer Pernasetti, et al. Combinations of tgfb inhibitors and cdk inhibitors for the treatment of breast cancer. Patent WO2020058820A1.
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